Publications

46. Stefanski KM, Li GC, Luu DD, Fosu KK, Guadarrama E, Hutchison JM, Saksena N, Zuy Y, Fisch AJ, Hasaka TP, Bauer JA, George AL, Kenworthy AK, Van Horn WD, Sanders CR. Protein-enhanced small molecule disruptors of ordered membrane domains. Proc. Natl. Acad. Sci. U.S.A. 2026 123(26):e2530579123. doi:10.1073/pnas.2530579123. PMID: 42335239

45. Stefanski KM, Huang H, Luu DD, Li GC, Hutchison JM, Saksena N, Fisch AJ, Hasaka TP, Bauer JA, Kenworthy AK, Van Horn WD, Sanders CR. Pharmacological tools to modulate ordered membrane domains and order-dependent protein function. Commun Chem. 2026 Jan 8;9(1):72. doi:10.1038/s42004-025-01874-8. PMID: 41507418

44. Sotelo-Morales JE, Mofidi Tabatabaei S, Fofie CK, Fosu KK, Dodd-O JB, Simcik RD, Tack SH, Soto-Reyes MJ, Yousuf MS, Caro-Diaz EJE, Kumar VA, Van Horn WD, Kolber B, Tidgewell KJ. Veraguamide E, a Marine Cyanobacterial Depsipeptide Targeting σ2R/TMEM97: Chemical and Neurobiological Characterization. J Nat Prod. 2025 Nov 28;88(11):2736-2749. doi:10.1021/acs.jnatprod.5c01092. PMID: 41195793

43. Mebrat MD, Luu DD, Hilton JK, Kim M, Parrott K, Cherry BR, Levitus M, Journigan VB, Van Horn WD. TRPM8 Protein Dynamics Correlates with Ligand Structure and Cellular Function. J Am Chem Soc. 2025 Jun 4;147(22):18460-18474. doi:10.1021/jacs.4c09435. PMID: 40421580

42. Scelsi HF, Close EGS, Huard DJE, Dunn E, Bogdanović N, Mudiyanselage SHW, Grant A, Stagg SM, Schmidt-Krey I, Van Horn WD, Lieberman RL. Detection of non-native species formed during fibrillization of the myocilin olfactomedin domain. Protein Sci. 2025 Apr;34(4):e70063. doi:10.1002/pro.70063. PMID: 40095382

41. Luu DD, Ramesh N, Kazan IC, Shah KH, Lahiri G, Mana MD, Ozkan SB, Van Horn WD. Evidence that the cold- and menthol-sensing functions of the human TRPM8 channel evolved separately. Sci Adv. 2024 Jun 21;10(25):eadm9228. doi:10.1126/sciadv.adm9228. PMID: 38905339

40. Saccuzzo EG, Mebrat MD, Scelsi HF, Kim M, Ma MT, Su X, Hill SE, Rheaume E, Li R, Torres MP, Gumbart JC, Van Horn WD, Lieberman RL. Competition between inside-out unfolding and pathogenic aggregation in an amyloid-forming β-propeller. Nat Commun. 2024 Jan 2;15(1):155. doi:10.1038/s41467-023-44479-2. PMID: 38168102

39. Orndorff PB, Poddar S, Owens AM, Kumari N, Ugaz BT, Amin S, Van Horn WD, van der Vaart A, Levitus M. Uracil-DNA glycosylase efficiency is modulated by substrate rigidity. Sci Rep. 2023 Mar 8;13(1):3915. doi:10.1038/s41598-023-30620-0. PMID: 36890276

38. Veldhuizen J, Mann HF, Karamanova N, Van Horn WD, Migrino RQ, Brafman D, Nikkhah M. Modeling long QT syndrome type 2 on-a-chip via in-depth assessment of isogenic gene-edited 3D cardiac tissues. Sci Adv. 2022 Dec 16;8(50):eabq6720. doi:10.1126/sciadv.abq6720. PMID: 36525500

37. Shekhar M, Terashi G, Gupta C, Sarkar D, Debussche G, Sisco NJ, Nguyen J, Mondal A, Vant J, Fromme P, Van Horn WD, Tajkhorshid E, Kihara D, Dill K, Perez A, Singharoy A. CryoFold: Determining protein structures and data-guided ensembles from cryo-EM density maps. Matter. 2021 4(10):3195-3216. doi:10.1016/j.matt.2021.09.004. PMID: 34671049

36. Hutchison JM, Capone R, Luu DD, Shah KH, Hadziselimovic A, Van Horn WD, Sanders CR. Recombinant SARS-CoV-2 envelope protein traffics to the trans-Golgi network following amphipol-mediated delivery into human cells. J. Biol. Chem. 2021 297(2):100940. doi:10.1016/j.jbc.2021.100940. PMID: 34237302

35. Journigan VB, Alarcón-Alarcón D, Feng Z, Wang Y, Liang T, Dawley DC, Amin ARMR, Montano C, Van Horn WD, Xie XQ, Ferrer-Montiel A, Fernández-Carvajal A. Structural and in Vitro Functional Characterization of a Menthyl TRPM8 Antagonist Indicates Species-Dependent Regulation. ACS Med Chem Lett. 2021 12(5):758-767. doi:10.1021/acsmedchemlett.1c00001. PMID: 34055223

34. Modi T, Risso VA, Martinez-Rodriguez S, Gavira JA, Mebrat MD, Van Horn WD, Sanchez-Ruiz JM, Banu Ozkan S. Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity. Nat Commun. 2021 12(1):1852. doi:10.1038/s41467-021-22089-0. PMID: 33767175

33. Kim M, Sisco NJ, Hilton JK, Montano CM, Castro MA, Cherry BR, Levitus M, Van Horn WD. Evidence that the TRPV1 S1-S4 membrane domain contributes to thermosensing. Nat Commun. 2020 11(1):4169. doi:10.1038/s41467-020-18026-2. PMID: 32820172

32. Sisco NJ, Luu DD, Kim M, Van Horn WD. PIRT the TRP Channel Regulating Protein Binds Calmodulin and Cholesterol-Like Ligands. Biomolecules. 2020 10(3):478. doi:10.3390/biom10030478. PMID: 32245175

31. Garami A, Shimansky YP, Rumbus Z, Vizin RCL, Farkas N, Hegyi J, Szakacs Z, Solymar M, Csenkey A, Chiche DA, Kapil R, Kyle DJ, Van Horn WD, Hegyi P, Romanovsky AA. Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis. Pharmacol Ther. 2020 208:107474. doi:10.1016/j.pharmthera.2020.107474. PMID: 31926897

30. Journigan VB, Feng Z, Rahman S, Wang Y, Amin ARMR, Heffner CE, Bachtel N, Wang S, Gonzalez-Rodriguez S, Fernández-Carvajal A, Fernández-Ballester G, Hilton JK, Van Horn WD, Ferrer-Montiel A, Xie XQ, Rahman T. Structure-Based Design of Novel Biphenyl Amide Antagonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 8 Channels with Potential Implications in the Treatment of Sensory Neuropathies. ACS Chem Neurosci. 2020 11(3):268-290. doi:10.1021/acschemneuro.9b00404. PMID: 31850745

29. Sisco NJ, Helsell CVM, Van Horn WD. Competitive Interactions between PIRT, the Cold Sensing Ion Channel TRPM8, and PIP2 Suggest a Mechanism for Regulation. Sci Rep. 2019 9(1):14128. doi:10.1038/s41598-019-49912-5. PMID: 31575973

28. Hilton JK, Kim M, Van Horn WD. Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels. Acc Chem Res. 2019 52(6):1643-1652. doi:10.1021/acs.accounts.9b00075. PMID: 31149807

27. Hilton JK, Salehpour T, Sisco NJ, Rath P, Van Horn WD. Phosphoinositide-interacting regulator of TRP (PIRT) has opposing effects on human and mouse TRPM8 ion channels. J Biol Chem. 2018 293(24):9423-9434. doi:10.1074/jbc.RA118.003563. PMID: 29724821

26. Hilton JK, Van Horn WD. New pieces to an old puzzle: identifying the warfarin-binding site that prevents clotting. Nat Struct Mol Biol. 2017 24(1):5-6. doi:10.1038/nsmb.3356. PMID: 28054569

25. Liao JY, Anosova I, Bala S, Van Horn WD, Chaput JC. A parallel stranded G-quadruplex composed of threose nucleic acid (TNA). Biopolymers. 2017 107(3). doi:10.1002/bip.22999. PMID: 27718227

24. Kroncke BM, Van Horn WD, Smith J, Kang C, Welch RC, Song Y, Nannemann DP, Taylor KC, Sisco NJ, George AL Jr, Meiler J, Vanoye CG, Sanders CR. Structural basis for KCNE3 modulation of potassium recycling in epithelia. Sci Adv. 2016 2(9):e1501228. doi:10.1126/sciadv.1501228. PMID: 27626070

23. Anosova I, Kowal EA, Sisco NJ, Sau S, Liao JY, Bala S, Rozners E, Egli M, Chaput JC, Van Horn WD. Structural Insights into Conformation Differences between DNA/TNA and RNA/TNA Chimeric Duplexes. Chembiochem. 2016 17(18):1705-8. doi:10.1002/cbic.201600349. PMID: 27347671

22. Anosova I, Kowal EA, Dunn MR, Chaput JC, Van Horn WD, Egli M. The structural diversity of artificial genetic polymers. Nucleic Acids Res. 2016 44(3):1007-21. doi:10.1093/nar/gkv1472. PMID: 26673703

21. Rath P, Hilton JK, Sisco NH, Van Horn WD. Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain. Biochemistry. 2016 55(1):114-24. doi:10.1021/acs.biochem.5b00931. PMID: 26653082

20. Zook J, Mo G, Sisco NJ, Craciunescu FM, Hansen DT, Baravati B, Cherry BR, Sykes K, Wachter R, Van Horn WD, Fromme P. NMR Structure of Francisella tularensis Virulence Determinant Reveals Structural Homology to Bet v1 Allergen Proteins. Structure. 2015 23:1116-1122. doi:10.1016/j.str.2015.03.025. PMID: 26004443

19. Hilton JK, Rath P, Helsell CVM, Beckstein O, Van Horn WD. Understanding Thermosensitive Transient Receptor Potential Channels as Versatile Polymodal Cellular Sensors. Biochemistry. 2015 54:2401-2413. doi:10.1021/acs.biochem.5b00071. PMID: 25812016

18. Van Horn WD. VKORC1 ER mislocalization causes rare disease. Blood. 2014 124(8):1215-16. doi:10.1182/blood-2014-07-586032. PMID: 25147380

17. Peng D, Kim JH, Kroncke BM, Law CL, Xia Y, Droege KD, Van Horn WD, Vanoye CG, Sanders CR. Purification and Structural Study of the Voltage-Sensor Domain of the Human KCNQ1 Potassium Ion Channel. Biochemistry. 2014 53(12):2032-42. doi:10.1021/bi500102w. PMID: 24606221

16. Van Horn WD. Structural and functional insights into human vitamin K epoxide reductase and vitamin K epoxide reductase-like 1. Crit. Rev. Biochem. Mol. Biol. 2013 48(4):357-72. doi:10.3109/10409238.2013.791659. PMID: 23631481

15. Barrett PJ, Chen J, Cho MK, Kim JH, Lu Z, Mathew S, Peng D, Song Y, Van Horn WD, Zhuang T, Sönnichsen FD, Sanders CR. The quiet renaissance of protein nuclear magnetic resonance. Biochemistry. 2013 52(8):1303-20. doi:10.1021/bi4000436. PMID: 23368985

14. Shi M, Pedchenko V, Greer BH, Van Horn WD, Santoro SA, Sanders CR, Hudson BG, Eichman BF, Zent R, Pozzi A. Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis. J Biol Chem. 2012 287(42):35139-52. doi:10.1074/jbc.M112.358648. PMID: 22888006

13. Barrett PJ, Song Y, Van Horn WD, Hustedt EJ, Schafer JM, Hadziselimovic A, Beel AJ, Sanders CR. The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol. Science. 2012 336(6085):1168-71. doi:10.1126/science.1219988. PMID: 22654059

12. Lu Z, Van Horn WD, Chen J, Mathew S, Zent R, Sanders CR. Bicelles at low concentrations. Mol Pharm. 2012 9(4):752-61. doi:10.1021/mp2004687. PMID: 22221179

11. Van Horn WD, Sanders CR. Prokaryotic diacylglycerol kinase and undecaprenol kinase. Annu Rev Biophys. 2012 41:81-101. doi:10.1146/annurev-biophys-050511-102330. PMID: 22224599

10. Van Horn WD, Vanoye CG, Sanders CR. Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel. Curr Opin Struct Biol. 2011 21(2):283-91. doi:10.1016/j.sbi.2011.01.001. PMID: 21296569

9. Kang C, Vanoye CG, Welch RC, Van Horn WD, Sanders CR. Functional delivery of a membrane protein into oocyte membranes using bicelles. Biochemistry. 2010 49(4):653-5. doi:10.1021/bi902155t. PMID: 20044833

8. Van Horn WD, Beel AJ, Kang C, Sanders CR. The impact of window functions on NMR-based paramagnetic relaxation enhancement measurements in membrane proteins. Biochim Biophys Acta. 2010 1798(2):140-9. doi:10.1016/j.bbamem.2009.08.022. PMID: 19751702

7. Kim HJ, Howell SC, Van Horn WD, Jeon YH, Sanders CR. Recent Advances in the Application of Solution NMR Spectroscopy to Multi-Span Integral Membrane Proteins. Prog Nucl Magn Reson Spectrosc. 2009 55(4):335-360. doi:10.1016/j.pnmrs.2009.07.003. PMID: 20161395

6. Van Horn WD, Kim HJ, Ellis CD, Hadziselimovic A, Sulistijo ES, Karra MD, Tian C, Sönnichsen FD, Sanders CR. Solution nuclear magnetic resonance structure of membrane-integral diacylglycerol kinase. Science. 2009 324(5935):1726-9. doi:10.1126/science.1171716. PMID: 19556511

5. Van Horn WD, Ogilvie ME, Flynn PF. Reverse micelle encapsulation as a model for intracellular crowding. J Am Chem Soc. 2009 131(23):8030-9. doi:10.1021/ja901871n. PMID: 19469539

4. Van Horn WD, Ogilvie ME, Flynn PF. Use of reverse micelles in membrane protein structural biology. J Biomol NMR. 2008 40(3):203-11. doi:10.1007/s10858-008-9227-5. PMID: 18297402

3. Flynn PF, Simorellis AK, Van Horn WD. NMR Studies of Encapsulated Macromolecules. Annu. Reports NMR Spectroscopy. 2007 62:179-219. doi:10.1016/S0066-4103(07)62004-3. PMID: 19829802

2. Simorellis AK, Van Horn WD, Flynn PF. Dynamics of low temperature induced water shedding from AOT reverse micelles. J Am Chem Soc. 2006 128(15):5082-90. doi:10.1021/ja0568401. PMID: 16608342

1. Van Horn WD, Simorellis AK, Flynn PF. Low-temperature studies of encapsulated proteins. J Am Chem Soc. 2005 127(39):13553-60. doi:10.1021/ja052805i. PMID: 16190719